TET2 anticorps (AA 1833-2002)

N° du produit ABIN7159637

Cet anticorps Lapin Polyclonal détecte spécifiquement TET2 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour TET2 anticorps (AA 1833-2002) (ABIN7159637)

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TET2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-TET2 anticorps

Épitope: AA 1833-2002

Fonction: TET2 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TET2

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Autre désignation: TET2

Sujet:

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Aliases: FLJ20032 antibody, KIAA1546 antibody, MDS antibody, Methylcytosine dioxygenase TET2 antibody, Nbla00191 antibody, Probable methylcytosine dioxygenase TET2 antibody, Protein Ayu17 449 antibody, Tet 2 antibody, Tet methylcytosine dioxygenase 2 antibody, Tet oncogene 2 antibody, Tet oncogene family member 2 antibody, TET2 antibody, TET2_HUMAN antibody

UniProt: Q6N021

Pathways: L'effet Warburg