MFGE8 anticorps

N° du produit ABIN7159679

Détail du produit anti-MFGE8 anticorps

Antigène: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MFGE8 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Protein G purified

Immunogène: Recombinant Human MFGE8 protein

Clone: 2B2D10

Isotype: IgG2b

Information d'application

Indications d'application: Recommended dilution:IHC:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MFGE8

Antigène: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Autre désignation: MFGE8 (MFGE8 Produits)

Synonymes: anticorps BA46, anticorps EDIL1, anticorps HMFG, anticorps HsT19888, anticorps MFG-E8, anticorps MFGM, anticorps OAcGD3S, anticorps SED1, anticorps SPAG10, anticorps hP47, anticorps ba46, anticorps edil1, anticorps oacgd3s, anticorps MGC75581, anticorps hst19888, anticorps MGC145109, anticorps MFGE8, anticorps mfge8, anticorps zgc:154157, anticorps MGC99228, anticorps AA408458, anticorps AI325141, anticorps Mfgm, anticorps P47, anticorps lactadherin, anticorps AGS, anticorps MFGME8, anticorps MFGMP-E8, anticorps im:6895406, anticorps mfge8l, anticorps zgc:110846, anticorps milk fat globule-EGF factor 8 protein, anticorps milk fat globule-EGF factor 8 protein b, anticorps milk fat globule-EGF factor 8 protein L homeolog, anticorps milk fat globule-EGF factor 8 protein a, anticorps MFGE8, anticorps mfge8, anticorps mfge8b, anticorps mfge8.L, anticorps Mfge8, anticorps mfge8a

Sujet:

Background: Human MFGE8(milk fat globule-EGF factor 8,also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas .Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII . Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59 % , 58 %, 56 %, and 52 % aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection . MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes . The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development .

Aliases: Lactadherin,Breast epithelial antigen,BA46 ,HMFG,MFGM Milk fat globule-EGF factor 8

UniProt: Q08431

Pathways: SARS-CoV-2 Protein Interactome