SIRT6 anticorps (AA 1-355)

N° du produit ABIN7160865

L’anticorps Lapin Polyclonal anti-SIRT6 a été validé pour ELISA. Il convient pour détecter SIRT6 dans des échantillons de Humain.

Aperçu rapide pour SIRT6 anticorps (AA 1-355) (ABIN7160865)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: ELISA

Détail du produit anti-SIRT6 anticorps

Épitope: AA 1-355

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human NAD-dependent protein deacetylase sirtuin-6 protein (1-355AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: SIRT6

Sujet:

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

Aliases: 2810449N18Rik antibody, AI043036 antibody, Mono ADP ribosyltransferase sirtuin 6 antibody, NAD-dependent protein deacetylase sirtuin-6 antibody, Regulatory protein SIR2 homolog 6 antibody, Regulatory protein SIR2 homolog antibody, SIR2 like 6 antibody, SIR2 like protein 6 antibody, Sir2 related protein type 6 antibody, SIR2-like protein 6 antibody, SIR2L6 antibody, SIR6_HUMAN antibody, SIRT 6 antibody, SIRT6 antibody, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody, Sirtuin 6 antibody, Sirtuin type 6 antibody, Sirtuin6 antibody

UniProt: Q8N6T7