COBRA1 anticorps (AA 8-199)

N° du produit ABIN7161139

Détail du produit anti-COBRA1 anticorps

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Épitope: AA 8-199

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COBRA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Negative elongation factor B protein (8-199AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur COBRA1

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Autre désignation: NELFB (COBRA1 Produits)

Synonymes: anticorps LOC100219583, anticorps COBRA1, anticorps NELF-B, anticorps bZ1O1.4, anticorps cobra1, anticorps cobra2, anticorps fe01e12, anticorps wu:fe01e12, anticorps zgc:55628, anticorps MGC131073, anticorps Cobra1, anticorps RGD1307832, anticorps A730008L03Rik, anticorps AB041607, anticorps AI663983, anticorps Nelf-b, anticorps cofactor of BRCA1, anticorps negative elongation factor complex member B, anticorps negative elongation factor complex member B L homeolog, anticorps LOC100219583, anticorps NELFB, anticorps nelfb, anticorps nelfb.L, anticorps Nelfb

Sujet:

Background: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.

Aliases: NELFB antibody, COBRA1 antibody, KIAA1182 antibody, Negative elongation factor B antibody, NELF-B antibody, Cofactor of BRCA1 antibody

UniProt: Q8WX92