NCOA1 anticorps (AA 284-393)

N° du produit ABIN7161856

Détail du produit anti-NCOA1 anticorps

Antigène: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Épitope: AA 284-393

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Nuclear receptor coactivator 1 protein (284-393AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NCOA1

Antigène: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Autre désignation: NCOA1 (NCOA1 Produits)

Synonymes: anticorps F-SRC-1, anticorps KAT13A, anticorps RIP160, anticorps SRC1, anticorps bHLHe42, anticorps bHLHe74, anticorps si:dkey-5g7.6, anticorps si:dkey-34f16.6, anticorps NCOA1, anticorps SRC-1, anticorps nuclear receptor coactivator 1, anticorps NCOA1, anticorps ncoa1, anticorps Ncoa1

Sujet:

Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Aliases: bHLHe74 antibody, Class E basic helix-loop-helix protein 74 antibody, F SRC 1 antibody, Hin 2 protein antibody, Hin2 protein antibody, MGC129719 antibody, MGC129720 antibody, mNRC 1 antibody, NCoA 1 antibody, NCoA-1 antibody, Ncoa1 antibody, NCOA1_HUMAN antibody, Nuclear receptor coactivator 1 antibody, Nuclear receptor coactivator protein 1 antibody, NY REN 52 antigen antibody, Protein Hin 2 antibody, Protein Hin-2 antibody, Protein Hin2 antibody, Renal carcinoma antigen NY REN 52 antibody, Renal carcinoma antigen NY-REN-52 antibody, RIP 160 antibody, RIP160 antibody, SRC 1 antibody, SRC-1 antibody, Steroid receptor coactivator 1 antibody

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha