TSC1 anticorps (pSer505) (Biotin)

N° du produit ABIN711973

Cet anticorps Lapin Polyclonal détecte spécifiquement TSC1 dans ELISA, WB, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Mouton.

Aperçu rapide pour TSC1 anticorps (pSer505) (Biotin) (ABIN711973)

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivité: Humain, Souris, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TSC1 anticorps (Biotin)

Épitope: pSer505

Réactivité croisée: Humain, Souris, Mouton

Homologie: Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: TSC1

Sujet:

Synonyms: TSC1phospho S505, LAM, TSC1, Tuberous sclerosis 1 protein.

Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

ID gène: 7248

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation