ETHE1 anticorps (AA 8-254)

N° du produit ABIN7163017

Détail du produit anti-ETHE1 anticorps

Antigène: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Épitope: AA 8-254

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETHE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ETHE1

Antigène: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Autre désignation: ETHE1 (ETHE1 Produits)

Synonymes: anticorps zgc:85680, anticorps HSCO, anticorps YF13H12, anticorps 0610025L15Rik, anticorps Hsco, anticorps ETHE1, persulfide dioxygenase, anticorps ethylmalonic encephalopathy 1, anticorps Ethe1, anticorps ethe1, anticorps ETHE1

Sujet:

Background: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

Aliases: Ethe1 antibody, ETHE1 protein, mitochondrial precursor antibody, ETHE1_HUMAN antibody, ethylmalonic encephalopathy 1 antibody, Ethylmalonic encephalopathy protein 1 antibody, hepatoma subtracted clone one antibody, Hepatoma subtracted clone one protein antibody, HSCO antibody, mitochondrial antibody, Protein ETHE1 antibody, Protein ETHE1 mitochondrial antibody, YF13H12 antibody

UniProt: O95571