PODXL anticorps
-
- Antigène Voir toutes PODXL Anticorps
- PODXL (Podocalyxin-Like (PODXL))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp PODXL est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF)
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Protein G purified
- Immunogène
- Recombinant Human PODXL protein
- Clone
- 4D2G7
- Isotype
- IgG2b
-
-
- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200, IP:1:200-1:2000,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Antigène
- PODXL (Podocalyxin-Like (PODXL))
- Autre désignation
- PODXL (PODXL Produits)
- Synonymes
- anticorps Gp200, anticorps PC, anticorps PCLP, anticorps PCLP-1, anticorps PCB, anticorps AW121214, anticorps Ly102, anticorps Pclp1, anticorps podocalyxin, anticorps MEP21, anticorps PODXL, anticorps Gp135, anticorps PCLP1, anticorps cPCLP1, anticorps podxl, anticorps fc18d02, anticorps wu:fc18d02, anticorps Pc, anticorps Pcb, anticorps Podxl, anticorps podocalyxin like, anticorps pyruvate carboxylase, anticorps podocalyxin-like, anticorps PODXL, anticorps PC, anticorps Podxl, anticorps podxl, anticorps Pcx
- Sujet
-
Background: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Aliases: Podocalyxin, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PC, PCLP-1, PODXL, PCLP, PCLP1
- UniProt
- O00592
- Pathways
- Tube Formation
-