PARN anticorps (AA 1-639)

N° du produit ABIN7163761

Cet anticorps anti-PARN est un anticorps Lapin Polyclonal détectant PARN dans WB, IHC, ELISA et IF. Adapté pour Humain.

Aperçu rapide pour PARN anticorps (AA 1-639) (ABIN7163761)

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-PARN anticorps

Épitope: AA 1-639

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Poly(A)-specific ribonuclease PARN protein (1-639AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PARN

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Autre désignation: PARN

Sujet:

Background: 3\\\'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3\\\'-end poly(A) tail and the 5\\\'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3\\\'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Aliases: DAN antibody, Deadenylating nuclease antibody, Deadenylation nuclease antibody, PARN antibody, PARN_HUMAN antibody, Poly A specific ribonuclease antibody, Poly(A) specific ribonuclease antibody, Poly(A)-specific ribonuclease PARN antibody, Polyadenylate specific ribonuclease antibody, Polyadenylate-specific ribonuclease antibody

UniProt: O95453