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PD-L1 anticorps (AA 19-238)

Name: PD-L1 anticorps (AA 19-238)
Brand: antibodies-online
SKU: ABIN7164674
Price: 415 EUR
Availability: InStock

PD-L1 Reactivité: Humain WB, FACS, IHC, ELISA, IF Hôte: Souris Monoclonal 9B5F4 unconjugated

Western Blot Positive WB detected in: A549 whole cell lysate, PC-3 whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate All lanes: PD-L1 antibody at 1:2500 Secondary Goat polyclonal to Mouse IgG at 1/10000 dilution Predicted band size: 33 kDa Observed band size: 55 kDa (PD-L1 anticorps (AA 19-238))

Overlay histogram showing A549 cells stained with ABIN7164674 (red line) at 1:150. (PD-L1 anticorps (AA 19-238))

FACS

Western Blot Positive WB detected in: Hela whole cell lysate All lanes: PD-L1 antibody at 1:1000, 1:2000, 1:4000 Secondary Goat polyclonal to Mouse IgG at 1/10000 dilution Predicted band size: 33 kDa Observed band size: 55 kDa (PD-L1 anticorps (AA 19-238))

IHC image of ABIN7164674 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. (PD-L1 anticorps (AA 19-238))

IHC

IHC image of ABIN7164674 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. (PD-L1 anticorps (AA 19-238))

IHC

Immunofluorescence staining of 293 cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 anticorps (AA 19-238))

Immunofluorescence staining of A549 cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 anticorps (AA 19-238))

Immunofluorescence staining of Hela cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 anticorps (AA 19-238))

Overlay histogram showing 293 cells stained with ABIN7164674 (red line) at 1:150. (PD-L1 anticorps (AA 19-238))

FACS

9 images

N° du produit ABIN7164674

Fiche de données

Antigène Voir toutes PD-L1 Anticorps

PD-L1 (CD274 (PD-L1))
Épitope
29

16

15

13

11

10

9

7

7

5

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 19-238
Reactivité
170

108

63

7

6

5

5

1

1
Humain
Hôte
127

61

17

4

4

1
Souris
Anticorps secondaires appropriés
Clonalité
108

104

2
Monoclonal
Conjugué
98

16

13

11

9

5

5

5

5

5

5

5

4

4

4

4

4

4

3

2

1

1

1
Cet anticorp PD-L1 est non-conjugé
Application
138

103

59

40

37

28

17

17

16

14

10

7

5

5

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée

Humain

Purification

Protein G purified

Immunogène

Recombinant Human Programmed cell death 1 ligand 1 protein (19-238AA)

Clone

9B5F4

Isotype

IgG2b

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PD-L1 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

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PD-L1 Reactivité: Humain IHC Hôte: Lapin Monoclonal unconjugated

anti-CD274 (PD-L1) (AA 34-241) antibody
PD-L1 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 24-153) antibody
PD-L1 Reactivité: Humain WB, FACS, IHC, ELISA, ICC Hôte: Souris Monoclonal 7D2A10 unconjugated

anti-CD274 (PD-L1) (C-Term) antibody
KO Validated PD-L1 Reactivité: Humain WB, FACS, ICC, IF, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 19-238) antibody
PD-L1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated

anti-CD274 (PD-L1) antibody
KO Validated PD-L1 Reactivité: Humain WB, IHC Hôte: Lapin Monoclonal unconjugated

Indications d'application

Recommended dilution: WB:1:1000-1:5000, IHC:1:50-1:200, IF:1:50-1:200, FC:1:100-1:300,

Restrictions

For Research Use only
Format

Liquid

Buffer

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur

ProClin

Précaution d'utilisation

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C,-80 °C

Stockage commentaire

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Antigène

PD-L1 (CD274 (PD-L1))

Autre désignation

PD-L1 (PD-L1 Produits)

Synonymes

anticorps B7-H, anticorps B7H1, anticorps PD-L1, anticorps PDCD1L1, anticorps PDCD1LG1, anticorps PDL1, anticorps A530045L16Rik, anticorps B7h1, anticorps Pdcd1l1, anticorps Pdcd1lg1, anticorps Pdl1, anticorps RGD1566211, anticorps CD274 molecule, anticorps CD274 antigen, anticorps programmed cell death 1 ligand 2, anticorps CD274, anticorps Cd274, anticorps PDCD1LG2

Sujet

Background: Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077)
Aliases: Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274), CD274, B7H1 PDCD1L1 PDCD1LG1 PDL1

UniProt

Q9NZQ7

Pathways

Cancer Immune Checkpoints