PRMT1 anticorps (AA 20-353)

N° du produit ABIN7165064

Cet anticorps Lapin Polyclonal détecte spécifiquement PRMT1 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour PRMT1 anticorps (AA 20-353) (ABIN7165064)

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PRMT1 anticorps

Épitope: AA 20-353

Fonction: PRMT1 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Protein arginine N-methyltransferase 1 protein (20-353AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRMT1

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Autre désignation: PRMT1

Sujet:

Background: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 \\\'Arg-4\\\' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.

Aliases: ANM 1 antibody, ANM1 antibody, ANM1_HUMAN antibody, HCP 1 antibody, HCP1 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody, Histone-arginine N-methyltransferase PRMT1 antibody, HMT 2 antibody, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody, HMT1 hnRNP methyltransferase antibody, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody, HMT1 hnRNP methyltransferase like 2 antibody, HMT2 antibody, HRMT1 L2 antibody, HRMT1L 2 antibody, HRMT1L2 antibody, Human mRNA for suppressor for yeast mutant antibody, Human mRNA for suppressor for yeast mutant complete cds antibody, Interferon receptor 1 bound protein 4 antibody, Interferon receptor 1 bound protein4 antibody, Interferon receptor 1-bound protein 4 antibody, Interferon receptor 1bound protein 4 antibody, IR1 B4 antibody, IR1B 4 antibody, IR1B4 antibody, Mrmt 1 antibody, Mrmt1 antibody, PRMT 1 antibody, PRMT1 antibody, Protein arginine methyltransferase 1 antibody, Protein arginine N methyltransferase 1 antibody, Protein arginine N methyltransferase1 antibody, Protein arginine N-methyltransferase 1 antibody, R1B4 antibody, S. cerevisiae like 2 antibody

UniProt: Q99873