JARID2 anticorps (AA 1-159) (FITC)

N° du produit ABIN7165674

L’anticorps Lapin Polyclonal anti-JARID2 a été validé pour . Il convient pour détecter JARID2 dans des échantillons de Humain.

Aperçu rapide pour JARID2 anticorps (AA 1-159) (FITC) (ABIN7165674)

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JARID2 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-JARID2 anticorps (FITC)

Épitope: AA 1-159

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protein Jumonji protein (1-159AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur JARID2

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Autre désignation: JARID2

Sujet:

Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \\\'Lys-27\\\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \\\'Lys-9\\\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Aliases: JARD2 antibody, JARD2_HUMAN antibody, JARID2 antibody, JMJ antibody, Jumonji AT rich interactive domain 2 antibody, Jumonji homolog antibody, Jumonji like protein antibody, Jumonji protein antibody, Jumonji/ARID domain containing protein 2 antibody, Jumonji/ARID domain-containing protein 2 antibody, Protein Jumonji antibody

UniProt: Q92833

Pathways: Chromatin Binding