REST anticorps (AA 250-350) (HRP)

N° du produit ABIN7167428

Cet anticorps Lapin Polyclonal détecte spécifiquement REST dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour REST anticorps (AA 250-350) (HRP) (ABIN7167428)

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REST est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-REST anticorps (HRP)

Épitope: AA 250-350

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RE1-silencing transcription factor protein (250-350AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur REST

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Autre désignation: REST

Sujet:

Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Aliases: Neural Restrictive Silencer Factor antibody, Neural-restrictive silencer factor antibody, Neuron Restrictive Silencer Factor antibody, NRSF antibody, RE1 silencing transcription factor antibody, RE1-silencing transcription factor antibody, Repressor binding to the X2 box antibody, rest antibody, REST protein antibody, REST_HUMAN antibody, X2 box repressor antibody, XBR antibody

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity