RGMA anticorps (AA 153-408)

N° du produit ABIN7167709

Détail du produit anti-RGMA anticorps

Antigène: RGMA (RGM Domain Family, Member A (RGMA))

Épitope: AA 153-408

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGMA est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Repulsive guidance molecule A protein (153-408AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RGMA

Antigène: RGMA (RGM Domain Family, Member A (RGMA))

Autre désignation: RGMA (RGMA Produits)

Synonymes: anticorps RGM, anticorps BC059072, anticorps C230063O06, anticorps repulsive guidance molecule family member a, anticorps repulsive guidance molecule family member A, anticorps RGMA, anticorps Rgma

Sujet:

Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

UniProt: Q96B86

Pathways: Tube Formation