PIM2 anticorps (AA 1-210)

N° du produit ABIN7169145

Détail du produit anti-PIM2 anticorps

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Épitope: AA 1-210

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIM2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase pim-2 protein (1-210AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIM2

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Autre désignation: PIM2 (PIM2 Produits)

Synonymes: anticorps cb1068, anticorps fj47b05, anticorps pim2, anticorps wu:fj47b05, anticorps DXCch3, anticorps Pim-2, anticorps Pim-2 proto-oncogene, serine/threonine kinase, anticorps proviral integration site 2, anticorps pim2, anticorps PIM2, anticorps Pim2

Sujet:

Background: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade, this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Aliases: OTTHUMP00000025825 antibody, Pim 2 oncogene antibody, Pim 2h antibody, Pim-2h antibody, PIM2 antibody, PIM2 Oncogene antibody, PIM2_HUMAN antibody, Pim2h antibody, Proto Oncogene PIM2 antibody, Proto-oncogene Pim-2 (serine threonine kinase) antibody, Serine/threonine kinase PIM2 antibody, Serine/threonine-protein kinase Pim-2 antibody

UniProt: Q9P1W9