SRRT anticorps (AA 627-876)

N° du produit ABIN7169355

L’anticorps Lapin Polyclonal anti-SRRT a été validé pour ELISA et IHC. Il convient pour détecter SRRT dans des échantillons de Humain.

Aperçu rapide pour SRRT anticorps (AA 627-876) (ABIN7169355)

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRRT est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SRRT anticorps

Épitope: AA 627-876

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SRRT

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Autre désignation: SRRT

Sujet:

Background: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA), however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Aliases: ARS2 protein antibody, Arsenate resistance protein ARS2 antibody, Arsenite resistance protein 2 antibody, Arsenite resistance protein antibody, Arsenite-resistance protein 2 antibody, ASR2 antibody, MGC126427 antibody, Serrate antibody, Serrate RNA effector molecule antibody, Serrate RNA effector molecule homolog (Arabidopsis) antibody, Serrate RNA effector molecule homolog antibody, SRRT antibody, SRRT_HUMAN antibody

UniProt: Q9BXP5

Pathways: Signalisation Notch, Stem Cell Maintenance