SPPL2B anticorps (AA 492-592) (HRP)

N° du produit ABIN7169630

Cet anticorps Lapin Polyclonal détecte spécifiquement SPPL2B dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour SPPL2B anticorps (AA 492-592) (HRP) (ABIN7169630)

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPPL2B est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-SPPL2B anticorps (HRP)

Épitope: AA 492-592

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SPPL2B

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Autre désignation: SPPL2B

Sujet:

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

Aliases: SPPL2B antibody, IMP4 antibody, KIAA1532 antibody, PSL1 antibody, Signal peptide peptidase-like 2B antibody, SPP-like 2B antibody, SPPL2b antibody, EC 3.4.23.- antibody, Intramembrane protease 4 antibody, IMP-4 antibody, Presenilin homologous protein 4 antibody, PSH4 antibody, Presenilin-like protein 1 antibody

UniProt: Q8TCT7