FAM33A anticorps (AA 1-121) (Biotin)

N° du produit ABIN7170592

Détail du produit anti-FAM33A anticorps (Biotin)

Antigène: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Épitope: AA 1-121

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM33A est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FAM33A

Antigène: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Autre désignation: SKA2 (FAM33A Produits)

Synonymes: anticorps FAM33A, anticorps 1110001A07Rik, anticorps C78640, anticorps Fam33a, anticorps RGD1307084, anticorps fam33a, anticorps spindle and kinetochore associated complex subunit 2, anticorps Spindle and kinetochore-associated protein 2, anticorps SKA2, anticorps Ska2, anticorps ska2

Sujet:

Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

Aliases: FAM33A antibody, Family with sequence similarity 33, member A antibody, FLJ12758 antibody, MGC110975 antibody, Protein FAM33A antibody, SKA 2 antibody, SKA2 antibody, SKA2_HUMAN antibody, Spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore associated protein 2 antibody, Spindle and kinetochore-associated protein 2 antibody, Spindle and KT (kinetochore) associated 2 antibody, Spindle and KT associated 2 antibody

UniProt: Q8WVK7

Pathways: M Phase