CXCL12 anticorps (AA 22-89)

N° du produit ABIN7170825

Détail du produit anti-CXCL12 anticorps

Antigène: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Épitope: AA 22-89

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCL12 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: >95%, Antigen Affinity purified & Affinity purified

Immunogène: Recombinant Human Stromal cell-derived factor 1 protein (22-89AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CXCL12

Antigène: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Autre désignation: CXCL12 (CXCL12 Produits)

Synonymes: anticorps IRH, anticorps PBSF, anticorps SCYB12, anticorps SDF1, anticorps TLSF, anticorps TPAR1, anticorps CINC-1, anticorps Gro1, anticorps Pbsf, anticorps Scyb12, anticorps Sdf1, anticorps Tlsf, anticorps Tpar1, anticorps Fsp, anticorps KC, anticorps Mgsa, anticorps N51, anticorps Scyb1, anticorps gro, anticorps sdf-1, anticorps sdf1, anticorps xSDF-1, anticorps SDF-1, anticorps cxcl12, anticorps sdf-1a, anticorps sdf1a, anticorps wu:fa55e10, anticorps wu:fc16h12, anticorps wu:fj84c02, anticorps C-X-C motif chemokine ligand 12, anticorps C-X-C motif chemokine ligand 1, anticorps chemokine (C-X-C motif) ligand 12, anticorps chemokine (C-X-C motif) ligand 1, anticorps C-X-C motif chemokine ligand 12 L homeolog, anticorps chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1), anticorps CXCL12, anticorps cxcl12, anticorps Cxcl1, anticorps Cxcl12, anticorps cxcl12.L, anticorps cxcl12a

Sujet:

Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody, AI174028 antibody, C-X-C motif chemokine 12 antibody, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody, Chemokine (C-X-C motif) ligand 12 antibody, Chemokine CXC motif ligand 12 antibody, cxcl12 antibody, hIRH antibody, hSDF-1 antibody, Intercrine reduced in hepatomas antibody, IRH antibody, OTTHUMP00000019491 antibody, PBSF antibody, Pre-B cell growth-stimulating factor antibody, SCYB12 antibody, SDF 1 antibody, SDF-1 antibody, SDF-1-alpha(3-67) antibody, SDF-1a antibody, SDF-1b antibody, SDF1_HUMAN antibody, SDF1A antibody, SDF1B antibody, Stromal cell-derived factor 1 antibody, Stromal cell-derived factor 1 delta antibody, Stromal cell-derived factor 1 gamma antibody, Stromal cell-derived factor 1a antibody, Stromal cell-derived factor-1 alpha antibody, Thymic lymphoma cell-stimulating factor antibody, Tlsf antibody, TLSF-a antibody, TLSF-b antibody, Tlsfa antibody, Tlsfb antibody, TPAR1 antibody

UniProt: P48061

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling