TERT anticorps (AA 281-436)

N° du produit ABIN7171713

L’anticorps Lapin Polyclonal anti-TERT a été validé pour ELISA et IHC. Il convient pour détecter TERT dans des échantillons de Humain.

Aperçu rapide pour TERT anticorps (AA 281-436) (ABIN7171713)

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TERT est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-TERT anticorps

Épitope: AA 281-436

Fonction: TERT Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Telomerase reverse transcriptase protein (281-436AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: TERT

Sujet:

Background: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Aliases: CMM9 antibody, DKCA2 antibody, DKCB4 antibody, EST2 antibody, HEST2 antibody, htert antibody, hTRT antibody, PFBMFT1 antibody, TCS1 antibody, Telomerase associated protein 2 antibody, Telomerase catalytic subunit antibody, Telomerase reverse transcriptase antibody, Telomerase-associated protein 2 antibody, Telomere Reverse Transcriptase antibody, TERT antibody, TERT_HUMAN antibody, TP2 antibody, TRT antibody

UniProt: O14746

Pathways: Telomere Maintenance