TLR6 anticorps (AA 32-586) (FITC)

N° du produit ABIN7172280

L’anticorps Lapin Polyclonal anti-TLR6 a été validé pour . Il convient pour détecter TLR6 dans des échantillons de Humain.

Aperçu rapide pour TLR6 anticorps (AA 32-586) (FITC) (ABIN7172280)

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR6 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-TLR6 anticorps (FITC)

Épitope: AA 32-586

Fonction: TLR6 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Toll-like receptor 6 protein (32-586AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TLR6

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Autre désignation: TLR6

Sujet:

Background: Participates in the innate immune response to bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Aliases: CD286 antibody, CD286 antigen antibody, TLR 6 antibody, Tlr6 antibody, TLR6_HUMAN antibody, Toll like receptor 6 precursor antibody, Toll-like receptor 6 antibody

UniProt: Q9Y2C9

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades