MIA3 anticorps (AA 1447-1626)

N° du produit ABIN7173309

L’anticorps Lapin Polyclonal anti-MIA3 a été validé pour ELISA. Il convient pour détecter MIA3 dans des échantillons de Humain.

Aperçu rapide pour MIA3 anticorps (AA 1447-1626) (ABIN7173309)

Antigène: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIA3 est non-conjugé

Application: ELISA

Détail du produit anti-MIA3 anticorps

Épitope: AA 1447-1626

Fonction: MIA3 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MIA3

Antigène: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Autre désignation: MIA3

Sujet:

Background: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of CTAGE5 and PREB/SEC12 to ERES (PubMed:28442536).

Aliases: ARNT antibody, C219 reactive peptide antibody, C219-reactive peptide antibody, D320 antibody, Melanoma inhibitory activity family, member 3 antibody, Melanoma inhibitory activity protein 3 antibody, Mia3 antibody, MIA3_HUMAN antibody, RP11-378J18.4 antibody, TANGO antibody, Transport and Golgi organization protein 1 antibody, UNQ6077 antibody

UniProt: Q5JRA6