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AXL anticorps (AA 312-447)

AXL Reactivité: Humain ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7174056
  • Antigène Voir toutes AXL Anticorps
    AXL (AXL Receptor tyrosine Kinase (AXL))
    Épitope
    • 20
    • 20
    • 20
    • 16
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-447
    Reactivité
    • 136
    • 62
    • 55
    • 6
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 123
    • 19
    • 3
    • 1
    Lapin
    Clonalité
    • 123
    • 23
    Polyclonal
    Conjugué
    • 59
    • 12
    • 11
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AXL est non-conjugé
    Application
    • 118
    • 69
    • 37
    • 26
    • 26
    • 21
    • 15
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)
    Isotype
    IgG
    Top Product
    Discover our top product AXL Anticorps primaire
  • Indications d'application
    Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    AXL (AXL Receptor tyrosine Kinase (AXL))
    Autre désignation
    AXL (AXL Produits)
    Synonymes
    anticorps JTK11, anticorps UFO, anticorps AI323647, anticorps Ark, anticorps Tyro7, anticorps Ufo, anticorps AXL receptor tyrosine kinase, anticorps Axl receptor tyrosine kinase, anticorps AXL, anticorps Axl
    Sujet

    Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

    Aliases: Adhesion related kinase antibody, AI323647 antibody, Ark antibody, Axl antibody, AXL oncogene antibody, AXL receptor tyrosine kinase antibody, AXL transforming gene antibody, AXL transforming sequence/gene antibody, EC 2.7.10.1 antibody, JTK11 antibody, Oncogene AXL antibody, Tyro7 antibody, Tyrosine protein kinase receptor UFO antibody, Tyrosine-protein kinase receptor UFO antibody, UFO antibody, UFO_HUMAN antibody

    UniProt
    P30530
    Pathways
    Signalisation RTK, Cellular Response to Molecule of Bacterial Origin
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