YES1 anticorps (AA 1-155)

N° du produit ABIN7174080

L’anticorps Lapin Polyclonal anti-YES1 a été validé pour WB, ELISA, IHC et IF. Il convient pour détecter YES1 dans des échantillons de Humain.

Aperçu rapide pour YES1 anticorps (AA 1-155) (ABIN7174080)

Antigène: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YES1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-YES1 anticorps

Épitope: AA 1-155

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tyrosine-protein kinase Yes protein (1-155AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur YES1

Antigène: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Autre désignation: YES1

Sujet:

Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Aliases: c Yes antibody, Cellular Yes 1 protein antibody, Cellular Yes1 protein antibody, HsT441 antibody, P61 YES antibody, p61-Yes antibody, Proto oncogene tyrosine protein kinase YES antibody, Proto-oncogene c-Yes antibody, Tyrosine-protein kinase Yes antibody, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody, Viral oncogene yes 1 homolog 1 antibody, Viral oncogene yes1 homolog 1 antibody, Yamaguchi sarcoma oncogene antibody, Yes 1 antibody, Yes antibody, YES proto oncogene 1, Src family tyrosine kinase antibody, YES_HUMAN antibody, YES1 antibody, YES1 proto oncogene, Src family tyrosine kinase antibody

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling