VPS11 anticorps (AA 692-941)

N° du produit ABIN7175282

Cet anticorps Lapin Polyclonal détecte spécifiquement VPS11 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour VPS11 anticorps (AA 692-941) (ABIN7175282)

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS11 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-VPS11 anticorps

Épitope: AA 692-941

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS11

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Autre désignation: VPS11

Sujet:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Aliases: END1 antibody, HGNC:14583 antibody, hVPS11 antibody, PEP5 antibody, PP3476 antibody, RING finger protein 108 antibody, RNF108 antibody, Vacuolar protein sorting 11 (yeast homolog) antibody, Vacuolar protein sorting 11 (yeast) antibody, Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody, Vacuolar protein sorting 11 homolog antibody, Vacuolar protein sorting associated protein 11 homolog antibody, Vacuolar protein sorting protein 11 antibody, Vacuolar protein sorting-associated protein 11 homolog antibody, vps11 antibody, VPS11_HUMAN antibody

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interactome