MMP2 anticorps (AA 412-662) (FITC)

N° du produit ABIN7176886

Cet anticorps anti-MMP2 est un anticorps Lapin Polyclonal détectant MMP2 dans . Adapté pour Souris.

Aperçu rapide pour MMP2 anticorps (AA 412-662) (FITC) (ABIN7176886)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP2 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-MMP2 anticorps (FITC)

Épitope: AA 412-662

Réactivité croisée: Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Mouse 72 kDa type IV collagenase protein (412-662AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: Mmp2

Sujet:

Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).By similarity PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).By similarity Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Aliases: Mmp2 antibody, 72 kDa type IV collagenase antibody, EC 3.4.24.24 antibody, 72 kDa gelatinase antibody, Gelatinase A antibody, Matrix metalloproteinase-2 antibody, MMP-2) [Cleaved into: PEX] antibody

UniProt: P33434

Pathways: Activation of Innate immune Response