FHIT anticorps (AA 2-150) (Biotin)

N° du produit ABIN7177010

Cet anticorps Lapin Polyclonal détecte spécifiquement FHIT dans ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour FHIT anticorps (AA 2-150) (Biotin) (ABIN7177010)

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FHIT est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-FHIT anticorps (Biotin)

Épitope: AA 2-150

Fonction: Fhit Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Mouse Bis(5\\\'-adenosyl)-triphosphatase protein (2-150AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FHIT

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Autre désignation: Fhit

Sujet:

Background: Cleaves P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5\\\'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor.

Aliases: FhitBis(5'-adenosyl)-triphosphatase antibody, EC 3.6.1.29 antibody, AP3A hydrolase antibody, AP3Aase antibody, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody, Dinucleosidetriphosphatase antibody, Fragile histidine triad protein antibody

UniProt: O89106