LOXL2 anticorps (AA 26-776)

N° du produit ABIN7177405

Cet anticorps anti-LOXL2 est un anticorps Lapin Polyclonal détectant LOXL2 dans WB et ELISA. Adapté pour Souris.

Aperçu rapide pour LOXL2 anticorps (AA 26-776) (ABIN7177405)

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LOXL2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-LOXL2 anticorps

Épitope: AA 26-776

Fonction: Loxl2 Antibody

Réactivité croisée: Humain

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LOXL2

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Autre désignation: Loxl2

Sujet:

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 By similarity. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Aliases: Loxl2Lysyl oxidase homolog 2 antibody, EC 1.4.3.13 antibody, Lysyl oxidase-like protein 2 antibody

UniProt: P58022

Pathways: Chromatin Binding