Notch1 anticorps (AA 21-338)

N° du produit ABIN7179798

L’anticorps Lapin Polyclonal anti-Notch1 a été validé pour ELISA. Il convient pour détecter Notch1 dans des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour Notch1 anticorps (AA 21-338) (ABIN7179798)

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Notch1 est non-conjugé

Application: ELISA

Détail du produit anti-Notch1 anticorps

Épitope: AA 21-338

Fonction: notch1a Antibody

Réactivité croisée: Poisson zèbre (Danio rerio)

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Notch1

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Autre désignation: notch1a

Sujet:

Background: Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Aliases: notch1a antibody, notch antibody, Neurogenic locus notch homolog protein 1 antibody, Notch 1) [Cleaved into: Notch 1 extracellular truncation antibody, NEXT), Notch 1 intracellular domain antibody, NICD)] antibody

UniProt: P46530

Pathways: Signalisation Notch, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development