TAL1 anticorps (AA 1-324)

N° du produit ABIN7179878

Détail du produit anti-TAL1 anticorps

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Épitope: AA 1-324

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Poisson zèbre (Danio rerio)

Purification: >95%, Protein G purified

Immunogène: Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TAL1

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Autre désignation: tal1 (TAL1 Produits)

Synonymes: anticorps SCL/tal-1, anticorps Scl, anticorps bHLHa17, anticorps tal-1, anticorps SCL, anticorps TCL5, anticorps scl, anticorps tcl5, anticorps SCL-alpha, anticorps SCL-beta, anticorps scl/tal1, anticorps zgc:85605, anticorps T cell acute lymphocytic leukemia 1, anticorps TAL bHLH transcription factor 1, erythroid differentiation factor, anticorps T-cell acute lymphocytic leukemia 1 S homeolog, anticorps T-cell acute lymphocytic leukemia 1, anticorps Tal1, anticorps TAL1, anticorps tal1.S, anticorps tal1

Sujet:

Background: Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.

Aliases: tal1 antibody, scl antibody, tal-1 antibody, si:ch211-135j1.3 antibody, T-cell acute lymphocytic leukemia protein 1 homolog antibody, TAL-1 antibody, Stem cell protein antibody, zSCL antibody

UniProt: O93507

Pathways: Stem Cell Maintenance