APLF anticorps (Ser116)

N° du produit ABIN7179974

Cet anticorps Lapin Polyclonal détecte spécifiquement APLF dans ELISA, WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour APLF anticorps (Ser116) (ABIN7179974)

Antigène: APLF (Aprataxin and PNKP Like Factor (APLF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APLF est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-APLF anticorps

Épitope: Ser116

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human APLF around the phosphorylation site of serine 116 (R-N-S(p)-Q-V).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur APLF

Antigène: APLF (Aprataxin and PNKP Like Factor (APLF))

Autre désignation: APLF

Sujet:

Background: Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.

Saunders W.S., J. Cell Sci. 104:573-582(1993).
Ye Q., J. Biol. Chem. 271:14653-14656(1996).
Ye Q., J. Biol. Chem. 272:14983-14989(1997).

Aliases: 2010301N04Rik antibody, AI452191 antibody, Aplf antibody, APLF_HUMAN antibody, Aprataxin and PNK-like factor antibody, Apurinic-apyrimidinic endonuclease APLF antibody, C2orf13 antibody, PNK and APTX like FHA protein antibody, PNK and APTX-like FHA domain-containing protein antibody, RGD1565557 antibody, XIP1 antibody, XRCC1 interacting protein 1 antibody, XRCC1-interacting protein 1 antibody

UniProt: Q8IW19

Pathways: Réparation de l'ADN