DDR1 anticorps (Tyr796)

N° du produit ABIN7180003

Cet anticorps anti-DDR1 est un anticorps Lapin Polyclonal détectant DDR1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour DDR1 anticorps (Tyr796) (ABIN7180003)

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DDR1 anticorps

Épitope: Tyr796

Fonction: DDR1 (Ab-796) Antibody

Réactivité croisée: Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human DDR1 around the phosphorylation site of tyrosine 796.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: DDR1

Sujet:

Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

di Marco E., J. Biol. Chem. 268:24290-24295(1993).
Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).

Aliases: CAK antibody, CD 167 antibody, CD167 antibody, CD167 antigen-like family member A antibody, CD167a antibody, Cell adhesion kinase antibody, DDR 1 antibody, DDR antibody, DDR1 antibody, DDR1_HUMAN antibody, Discoidin domain receptor antibody, Discoidin domain receptor tyrosine kinase 1 antibody, Discoidin receptor tyrosine kinase antibody, Discoidin receptor tyrosine kinase isoform a antibody, EDDR 1 antibody, EDDR1 antibody, Epithelial discoidin domain receptor 1 antibody, Epithelial discoidin domain-containing receptor 1 antibody, Epithelial specific receptor kinase antibody, HGK2 antibody, Mammarian carcinoma kinase 10 antibody, Mammary carcinoma kinase 10 antibody, MCK-10 antibody, MCK10 antibody, NEP antibody, Neuroepithelial tyrosine kinase antibody, Neurotrophic tyrosine kinase receptor type 4 antibody, NTRK 4 antibody, NTRK4 antibody, OTTHUMP00000029343 antibody, OTTHUMP00000029344 antibody, OTTHUMP00000029345 antibody, OTTHUMP00000029346 antibody, OTTHUMP00000029347 antibody, OTTHUMP00000164863 antibody, OTTHUMP00000164867 antibody, OTTHUMP00000222080 antibody, Protein-tyrosine kinase 3A antibody, Protein-tyrosine kinase RTK-6 antibody, PTK 3 antibody, PTK 3A protein tyrosine kinase 3A antibody, PTK3 antibody, PTK3A antibody, Receptor tyrosine kinase NEP antibody, RTK 6 antibody, RTK6 antibody, TRK E antibody, TRKE antibody, Tyrosine kinase DDR antibody, Tyrosine kinase receptor E antibody, Tyrosine-protein kinase CAK antibody

UniProt: Q08345

Pathways: Signalisation RTK, Smooth Muscle Cell Migration