MSK2 anticorps (Thr568)

N° du produit ABIN7180050

L’anticorps Lapin Polyclonal anti-MSK2 a été validé pour WB et ELISA. Il convient pour détecter MSK2 dans des échantillons de Humain.

Aperçu rapide pour MSK2 anticorps (Thr568) (ABIN7180050)

Antigène: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MSK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MSK2 anticorps

Épitope: Thr568

Fonction: RPS6KA4 (Ab-568) Antibody

Réactivité croisée: Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C).

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MSK2

Antigène: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Autre désignation: RPS6KA4

Sujet:

Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Pierrat B.,J. Biol. Chem. 273:29661-29671(1998).
Deak M.,EMBO J. 17:4426-4441(1998).
Soloaga A.,EMBO J. 22:2788-2797(2003).

Aliases: 90 kDa ribosomal protein S6 kinase 4 antibody, EC 2.7.11.1 antibody, KS6A4_HUMAN antibody, Mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen- and stress-activated protein kinase 2 antibody, Ribosomal protein kinase B antibody, Ribosomal protein S6 kinase 90kD polypeptide 4 antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 4 antibody, Ribosomal protein S6 kinase alpha 4 antibody, Ribosomal protein S6 kinase alpha-4 antibody, RPS6KA4 antibody, RSKB antibody, S6K-alpha-4 antibody

UniProt: O75676