NDFIP1 anticorps (C-Term)

N° du produit ABIN7180214

Cet anticorps Lapin Polyclonal détecte spécifiquement NDFIP1 dans ELISA et WB. Il présente une réactivité envers Humain.

Aperçu rapide pour NDFIP1 anticorps (C-Term) (ABIN7180214)

Antigène: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDFIP1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-NDFIP1 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human NDFIP1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NDFIP1

Antigène: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Autre désignation: NDFIP1

Sujet:

Background: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.

Petroziello J.M., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Matsuda A., Oncogene 22:3307-3318(2003).
Otsuki T., DNA Res. 12:117-126(2005).

Aliases: 0610010M22Rik antibody, Breast cancer associated protein SGA 1M antibody, Breast cancer-associated protein SGA-1M antibody, MGC10924 antibody, N4WBP5 antibody, Ndfip1 antibody, Nedd4 family interacting protein 1 antibody, NEDD4 family-interacting protein 1 antibody, NEDD4 WW domain binding protein 5 antibody, NEDD4 WW domain-binding protein 5 antibody, NFIP1_HUMAN antibody, Putative MAPK activating protein PM13 antibody, Putative MAPK-activating protein PM13 antibody, Putative NF kappa B activating protein 164 antibody, Putative NF-kappa-B-activating protein 164 antibody, Putative NFKB and MAPK activating protein antibody, Putative NFKB and MAPK-activating protein antibody

UniProt: Q9BT67

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Negative Regulation of Transporter Activity