CCAR2 anticorps

N° du produit ABIN7183705

Cet anticorps anti-CCAR2 est un anticorps Lapin Polyclonal détectant CCAR2 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour CCAR2 anticorps (ABIN7183705)

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCAR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CCAR2 anticorps

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human KIAA1967.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CCAR2

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Autre désignation: CCAR2

Sujet:

Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.

Nagase T., DNA Res. 8:319-327(2001).
Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).
Olsen J.V., Cell 127:635-648(2006).

Aliases: CCAR2 antibody, DBC1 antibody, KIAA1967Cell cycle and apoptosis regulator protein 2 antibody, Cell division cycle and apoptosis regulator protein 2 antibody, DBIRD complex subunit KIAA1967 antibody, Deleted in breast cancer gene 1 protein antibody, DBC-1 antibody, DBC.1 antibody, NET35 antibody, p30 DBC antibody

UniProt: Q8N163