CCAR2 anticorps

N° du produit ABIN7183705

Détail du produit anti-CCAR2 anticorps

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCAR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human KIAA1967.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CCAR2

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Autre désignation: CCAR2 (CCAR2 Produits)

Synonymes: anticorps DBC-1, anticorps DBC1, anticorps KIAA1967, anticorps NET35, anticorps p30 DBC, anticorps p30DBC, anticorps 2610301G19Rik, anticorps mKIAA1967, anticorps RGD1309922, anticorps Kiaa1967, anticorps cell cycle and apoptosis regulator 2, anticorps cell cycle activator and apoptosis regulator 2, anticorps CCAR2, anticorps Ccar2

Sujet:

Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.

Nagase T., DNA Res. 8:319-327(2001).
Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).
Olsen J.V., Cell 127:635-648(2006).

Aliases: CCAR2 antibody, DBC1 antibody, KIAA1967Cell cycle and apoptosis regulator protein 2 antibody, Cell division cycle and apoptosis regulator protein 2 antibody, DBIRD complex subunit KIAA1967 antibody, Deleted in breast cancer gene 1 protein antibody, DBC-1 antibody, DBC.1 antibody, NET35 antibody, p30 DBC antibody

UniProt: Q8N163