BARD1 anticorps (N-Term)

N° du produit ABIN7184419

Cet anticorps anti-BARD1 est un anticorps Lapin Polyclonal détectant BARD1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour BARD1 anticorps (N-Term) (ABIN7184419)

Antigène: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BARD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-BARD1 anticorps

Épitope: N-Term

Fonction: BARD1 Antibody

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from N-terminal of Human BARD1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BARD1

Antigène: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Autre désignation: BARD1

Sujet:

Background: Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Wu L.C., Nat. Genet. 14:430-440(1996).
Thai T.H., Hum. Mol. Genet. 7:195-202(1998).
Hillier L.W., Nature 434:724-731(2005).

Aliases: BARD-1 antibody, Bard1 antibody, BARD1_HUMAN antibody, BRCA1 associated RING domain 1 antibody, BRCA1 associated RING domain gene 1 antibody, BRCA1 associated RING domain protein 1 antibody, BRCA1-associated RING domain protein 1 antibody

UniProt: Q99728

Pathways: Réparation de l'ADN