IL21 Receptor anticorps (AA 20-232)

N° du produit ABIN7193230

Cet anticorps Souris Monoclonal détecte spécifiquement IL21 Receptor dans ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour IL21 Receptor anticorps (AA 20-232) (ABIN7193230)

Antigène: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL21 Receptor est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: 8H10G4D12

Détail du produit anti-IL21 Receptor anticorps

Épitope: AA 20-232

Fonction: CD360 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD360 (AA: 20-232) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur IL21 Receptor

Antigène: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Autre désignation: CD360

Sujet:

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Poids moléculaire: 59.1 kDa

UniProt: Q9HBE5

Pathways: Signalistation JAK/STAT