MLL/KMT2A anticorps (AA 801-956)

N° du produit ABIN7193384

L’anticorps Souris Monoclonal anti-MLL/KMT2A a été validé pour ELISA. Il convient pour détecter MLL/KMT2A dans des échantillons de Humain.

Aperçu rapide pour MLL/KMT2A anticorps (AA 801-956) (ABIN7193384)

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLL/KMT2A est non-conjugé

Application: ELISA

Clone: 4A5A12

Détail du produit anti-MLL/KMT2A anticorps

Épitope: AA 801-956

Fonction: KMT2A Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human KMT2A (AA: 801-956) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur MLL/KMT2A

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: KMT2A

Sujet:

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Poids moléculaire: 431.7 kDa

ID gène: 4297

UniProt: Q03164

Pathways: L'effet Warburg