SETD7 anticorps (AA 107-366)

N° du produit ABIN7193392

Cet anticorps Souris Monoclonal détecte spécifiquement SETD7 dans WB, ELISA et FACS. Il présente une réactivité envers Humain, Rat et Singe.

Aperçu rapide pour SETD7 anticorps (AA 107-366) (ABIN7193392)

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SETD7 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 1B3B8

Détail du produit anti-SETD7 anticorps

Épitope: AA 107-366

Fonction: SETD7 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur SETD7

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Autre désignation: SETD7

Sujet:

Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Poids moléculaire: 40.7 kDa

UniProt: Q8WTS6