Perforin 1 anticorps (AA 148-372)

N° du produit ABIN7193869

Cet anticorps Souris Monoclonal détecte spécifiquement Perforin 1 dans WB, IHC, ELISA et FACS. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Perforin 1 anticorps (AA 148-372) (ABIN7193869)

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Perforin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 8A8C10

Détail du produit anti-Perforin 1 anticorps

Épitope: AA 148-372

Fonction: PRF1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human PRF1 (AA: 148-372) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur Perforin 1

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Autre désignation: PRF1

Sujet:

This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.

Poids moléculaire: 61.3 kDa

ID gène: 5551

UniProt: P14222

Pathways: Apoptose, Caspase Cascade in Apoptosis