TLR7 anticorps (AA 420-644)

N° du produit ABIN7193966

L’anticorps Souris Monoclonal anti-TLR7 a été validé pour ELISA et FACS. Il convient pour détecter TLR7 dans des échantillons de Humain.

Aperçu rapide pour TLR7 anticorps (AA 420-644) (ABIN7193966)

Antigène: TLR7 (Toll-Like Receptor 7 (TLR7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR7 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: 3A9E11

Détail du produit anti-TLR7 anticorps

Épitope: AA 420-644

Fonction: TLR7 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human TLR7 (AA: 420-644) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur TLR7

Antigène: TLR7 (Toll-Like Receptor 7 (TLR7))

Autre désignation: TLR7

Sujet:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well, in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.

Poids moléculaire: 120 kDa

ID gène: 51284

UniProt: Q9NYK1

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades