Sclerostin anticorps (Cy5)

N° du produit ABIN715590

Cet anticorps anti-Sclerostin est un anticorps Lapin Polyclonal détectant Sclerostin dans WB et IF (p). Adapté pour Humain, Souris, Rat, Chien et Porc.

Aperçu rapide pour Sclerostin anticorps (Cy5) (ABIN715590)

Antigène: Sclerostin (SOST)

Reactivité: Humain, Souris, Rat, Chien, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sclerostin est conjugé à/à la Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Sclerostin anticorps (Cy5)

Réactivité croisée: Chien, Humain, Souris, Porc, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Sclerostin

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Sclerostin

Antigène: Sclerostin (SOST)

Autre désignation: Sclerostin

Sujet:

Synonyms: BEER, Cortical hyperostosis with syndactyly, Sclerosteosis, Sclerostin, SOST, SOST_HUMAN, VBCH.

Background: Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways.

Poids moléculaire: 24-28kDa

ID gène: 50964