ACER1 anticorps (AA 100-180)

N° du produit ABIN7226610

Cet anticorps anti-ACER1 Polyclonal Lapin (ABIN7226610) détecte spécifiquement ACER1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ACER1 anticorps (AA 100-180) (ABIN7226610)

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACER1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ACER1 anticorps

Épitope: AA 100-180

Fonction: ASAH3 Polyclonal Antibody

Specificité: ASAH3 Polyclonal Antibody detects endogenous levels of ASAH3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the Internal region of human ASAH3 at AA range: 100-180

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur ACER1

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Autre désignation: ASAH3

Sujet: Rabbit Anti-ASAH3 Polyclonal Antibody,ACER1, ASAH3, Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3,Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 (alkaline ceramidase 1) is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.,Alkaline ceramidase 1

ID gène: 125981

UniProt: Q8TDN7