CROT anticorps (pSer400)

N° du produit ABIN7219574

Cet anticorps anti-CROT est un anticorps Lapin Polyclonal détectant CROT dans ELISA et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CROT anticorps (pSer400) (ABIN7219574)

Antigène: CROT (Carnitine O-Octanoyltransferase (CROT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CROT est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CROT anticorps

Épitope: pSer400

Fonction: Cot (phospho Ser400) Polyclonal Antibody

Specificité: Phospho-Cot (S400) Polyclonal Antibody detects endogenous levels of Cot protein only when phosphorylated at S400.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from human Cot Phospho-Ser400

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur CROT

Antigène: CROT (Carnitine O-Octanoyltransferase (CROT))

Autre désignation: Cot

Sujet: Rabbit Anti-Cot (phospho Ser400) Polyclonal Antibody,MAP3K8, COT, ESTF, Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2,MAP3K8 is an oncogene that encodes a member of the serine/threonine protein kinase family. The mitogen-activated protein kinase kinase kinase 8 localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.,Mitogen-activated protein kinase kinase kinase 8

ID gène: 1326

UniProt: P41279

Pathways: Monocarboxylic Acid Catabolic Process