CD72 anticorps (Internal Region)

N° du produit ABIN7226672

Cet anticorps anti-CD72 est un anticorps Lapin Polyclonal détectant CD72 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour CD72 anticorps (Internal Region) (ABIN7226672)

Antigène: CD72 (CD72 Molecule (CD72))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD72 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CD72 anticorps

Épitope: Internal Region

Fonction: CD72 Polyclonal Antibody

Specificité: CD72 Polyclonal Antibody detects endogenous levels of CD72 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the Internal region of human CD72

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur CD72

Antigène: CD72 (CD72 Molecule (CD72))

Autre désignation: CD72

Sujet: Rabbit Anti-CD72 Polyclonal Antibody,CD72, B-cell differentiation antigen CD72, Lyb-2, CD72,CD5 has been identified as a transmembrane glycoprotein that is expressed on 70 % of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/CD3 ζ chain, and with the Src family kinase, Lck p56. The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The ability of lymphocytes to respond to antigenic or mitogenic stimulation utilizes both positive and negative regulatory proteins that influence the threshold for responsiveness. The human CD72 gene maps to chromosome 9p13.3 and encodes a transmembrane glycoprotein that contains an immunoreceptor tyrosine-based inhibition motif (ITIM). Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells.,B-cell differentiation antigen CD72

Poids moléculaire: observerd band 40kDa

ID gène: 971

UniProt: P21854

Pathways: BCR Signaling