DERL1 anticorps

N° du produit ABIN7228186

L’anticorps anti-DERL1 Polyclonal Lapin est utilisé pour la détection de DERL1 dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour DERL1 anticorps (ABIN7228186)

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DERL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DERL1 anticorps

Fonction: Rabbit Anti-DERL1 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of DERL1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human DERL1 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur DERL1

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Autre désignation: DERL1

Sujet: Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1The protein encoded by DERL1 gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Poids moléculaire: 27kD

ID gène: 79139

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling