NEIL2 anticorps

N° du produit ABIN7229952

L’anticorps anti-NEIL2 Polyclonal Lapin est utilisé pour la détection de NEIL2 dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour NEIL2 anticorps (ABIN7229952)

Antigène: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEIL2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NEIL2 anticorps

Fonction: Rabbit Anti-NEIL2 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of NEIL2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human NEIL2 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NEIL2

Antigène: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Autre désignation: NEIL2

Sujet: Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2NEIL2 encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified.

Poids moléculaire: 36kD

ID gène: 252969

UniProt: Q969S2

Pathways: Réparation de l'ADN