FRS2 anticorps

N° du produit ABIN7214962

Cet anticorps anti-FRS2 Polyclonal Lapin (ABIN7214962) détecte spécifiquement FRS2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour FRS2 anticorps (ABIN7214962)

Antigène: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRS2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FRS2 anticorps

Fonction: Rabbit Anti-FRS2 Polyclonal Antibody

Specificité: FRS2 Polyclonal Antibody detects endogenous levels of FRS2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FRS2

Antigène: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Autre désignation: FRS2

Sujet: FRS2, Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1FRS2 is a gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. Fibroblast growth factor receptor substrate 2 plays a key role in activating MAP kinases and in phosphorylating PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Fibroblast growth factor receptor substrate 2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.

Poids moléculaire: 65kD

ID gène: 10818

UniProt: Q8WU20

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2