FGFRL1 anticorps (AA 130-210)

N° du produit ABIN7223224

Cet anticorps anti-FGFRL1 Polyclonal Lapin (ABIN7223224) détecte spécifiquement FGFRL1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour FGFRL1 anticorps (AA 130-210) (ABIN7223224)

Antigène: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFRL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FGFRL1 anticorps

Épitope: AA 130-210

Fonction: Rabbit Anti-FGFR-5 Polyclonal Antibody

Specificité: FGFR-5 Polyclonal Antibody detects endogenous levels of FGFR-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human FGFR-5 at AA range: 130-210

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FGFRL1

Antigène: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Autre désignation: FGFR-5

Sujet: FGFRL1, FGFR5, FHFR, Fibroblast growth factor receptor-like 1, FGF receptor-like protein 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5, FGFR-5The protein encoded by FGFRL1 (fibroblast growth factor receptor-like 1) is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for FGFRL1.

Poids moléculaire: 54kD

ID gène: 53834

UniProt: Q8N441

Pathways: Signalisation RTK